Clearly, newer agents are needed for treatment of these disorders, and investigators have proposed studies that evaluate agents that target these malignancies and the microenvironment depending upon the molecular mechanisms thought to underlie their pathogenesis. ![]() Since 2006, the USFDA has approved five medications for treatment of these diseases, and only anti-CD30-therapy has made a change in these statistics. Most patients with relapsed disease succumb within 2 to 3 years. Although widely accepted chemotherapeutic agents and combinations, including stem cell transplantation, obtain responses as initial therapy for these diseases, most patients will develop a relapse, and the median survival is only 5 years. Recent molecular studies have revealed a wide array of different mechanisms that drive the development of these malignancies and may be associated with resistance to therapies. T-cell lymphomas are a relatively rare group of malignancies with a diverse range of pathologic features and clinical behaviors. Ces résultats suggèrent un protocole de soins alternant vaccination et chimiothérapie à des moments spécifiques du cycle. J'interprète l'existence d'oscillations dans ce système loin de l'équilibre par la présence d'interactions autocatalytiques et de boucles de rétroaction induites par la dépendance des taux d'interaction en fonction de l'activité relative des cellules. Enfin, j'étends les équations cinétiques et leur simulation à la description spatiale de la croissance d'une tumeur et montre que le modèle reproduit des oscillations temporelles, stimulées par la formation locale d'amas de cellules d'activité plus grande. Pour une valeur critique du champ contrôlant les fluctuations de l'activité cellulaire, le modèle reproduit le phénomène des 3 E de l'immunothérapie (élimination, équilibre et échappement du cancer). Je réalise ensuite une analyse de sensibilité aux paramètres d’un modèle homogène dans le cadre de la théorie cinétique thermostatée, en m’appuyant sur des simulations de Monte Carlo cinétique. Je présente d’abord un modèle macroscopique homogène décrivant la dynamique des concentrations et des activités moyennes des cellules et reproduisant des oscillations temporelles observées cliniquement. Therefore, further research is needed in this regard as well as the utility of Tregs as prognostic factors and therapy strategies in different lymphomas.Ĭe travail concerne la modélisation des interactions entre cellules du système immunitaire et cancéreuses, susceptibles d'augmenter leur activité par apprentissage lors d'interactions favorables. However, the mechanisms underlying the various roles of Tregs in patients with lymphomas remain unknown. In contrast, in patients with lymphomas where Tregs serve as tumor-killing Tregs and incompetent Tregs, anti-tumor cytotoxicity is enhanced or anti-autoimmune Tregs activities are weakened thus increased numbers of Tregs are associated with a good prognosis and reduced numbers of Tregs are associated with a poor prognosis. In patients with lymphomas where Tregs serve either as suppressor Tregs or malignant Tregs, anti-tumor cytotoxicity is suppressed thus decreased numbers of Tregs are associated with a good prognosis. The classification into four groups is significant in predicting prognosis and designing Tregs-based immunotherapies for treating lymphomas. ![]() Based on characterized roles of Tregs in lymphomas, we can categorize the various roles into four groups: (a) suppressor Tregs (b) malignant Tregs (c) direct tumor-killing Tregs and (d) incompetent Tregs. Assessment of Treg phenotypes and genotypes in patients may offer prediction of outcome in many types of lymphomas including diffuse large B-cell lymphoma, follicular lymphoma, cutaneous T cell lymphoma, and Hodgkin's lymphoma. Recent studies revealed that some lymphoma T cells might adopt a Treg profile. Lymphomas are a group of serious and frequently fatal malignant diseases of lymphocytes. Tregs represent important modulators for the interaction between lymphomas and host microenvironment. Regulatory T cells (Tregs) are a specialized subpopulation of CD4(+) T cells, which act to suppress the activation of other immune cells.
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